FROM: www.Dr.

Please note:

This regimen is usually recommended only for people with established cardiovascular disease or those who have an elevated LP(a) level.

Most researchers do not advocate this vitamin regimen for generalized protection from cardiovascular disease.

For most of us, simply taking our 2 to 3 grams of vitamin C daily should suffice

However, if your LP(a) is elevated (greater than 10 mg/dl) then you will need more aggressive measures.

The most important part of the program will be to follow a diet, which will reduce your insulin levels and improve your HDL/cholesterol ratio. Your diet will not alter the LP(a) levels, but it will minimize other risk factors for heart disease.

The mega vitamin therapy increases blood concentrations of important substances and will:

* Strengthen and heal blood vessels,

* Lower LP(a) blood levels and

* Keep LP(a) levels low

* Inhibit the binding of LP(a) molecules to the walls of blood vessels

Unlike ordinary drugs, there are no health risks. We call high intakes of these substances, esp. vitamin C and lysine, The Pauling Therapy. The Pauling Therapy helps treat the root cause and our experience shows it can rapidly reverse advanced heart disease.

How Much Vitamin C And Lysine Should I Take?

The amount will vary between individuals. Seriously ill heart patients require 5-6 grams of vitamin C and 5-6 grams of lysine daily. That is, 5,000 to 6,000 mg of each in divided doses throughout the day.
The new protocol would also be to include L-carnitine, a natural compound stimulating fatty acid oxidation in the mitochondria. The dose would be 2 grams per day or 500 mg four times a day and the amino acid proline at the same dosage as L-lysine.

This recommendation comes from a study that was published in October of 2000 from Italian researchers at the University of Milan. (Dirtori Cr, et al: L-Carnitine Reduces Plasma Lipoprotein(a) levels in patients with hyper LP(a). Nutr Metab Cardiovas Dis 2000 Oct 10 (5):247-51.)

Ideally this should be split into four evenly divided doses.

The lysine works by binding to the LP(a) and if you only take it once a day, there will be a large part of the day where you will not be getting protection as the lysine will be eliminated from the blood within a few hours.

The Pauling “mega” dose ranges are based on the degree of illness. In general, Lp(a) binding inhibitors are food substances that are non-toxic and studies have shown they improve health as intake increases. Lesser amounts will have lesser effects. According to his daughter Linda, Linus Pauling’s lysine dosage recommendations were carefully considered. Pauling based his recommendations on knowledge of lysine blood serum levels after intake.

It is not practical to obtain these amounts in food alone. Supplements are required.

It may not be a coincidence that vitamin C, and the amino acids lysine and proline are the fundamental building blocks of collagen. The Pauling Therapy provides these building blocks in ample amounts. Over time, collagen must be replenished for blood vessels to remain healthy and plaque free.

Report after report provides more evidence that the Pauling Therapy, at high doses, works in many people within 14 to 60 days (depending on the daily dosage). A few have reported that the therapy didn’t change their condition, or else required much longer, sometimes over 10 months.

But so far most people (>90%) report relief in weeks rather than months. Lp(a) levels in the blood provide objective evidence. People share their lab reports with us. These reports document drops in serum Lp(a) up to 88%. With longer term use the values continue to decline and usually drop to less than 14. So far, the higher the starting value, the larger the point drop. It is not surprising that most doctors won’t take our word for it and require solid scientific evidence. The question is:

Why haven’t serious clinical studies been run years ago?

Regrowth of plaque is common. Patients risk strokes and other side effects; pieces of plaque may break free during the surgical procedure causing a blockage. According to a recent Discovery-Health channel report, roughly 40% of patients who are put on a heart-lung machine suffer brain damage. On the other hand, to our limited knowledge, there has yet to be single death of a “terminal” patient who adopted and continued the Pauling Therapy.

Other Adjunctive Supplements

It would be wise to take a good form of vitamin E. There are many good ones on the market, but make certain that yours is not synthetic and has a mixed form of tocopherols present. Additionally, tocotrienols will also be useful.

Having a hair analysis done from Trace Elements will also help optimize your requirements for specific adjunctive minerals. If you take a mineral that your body does not need, it can actually worsen your condition.


Elevated levels of Lp(a) are frequently overlooked by traditional medicine as a cause of heart disease. It is something that I screen for though on all our patients at high risk for heart disease.

Part of the reason why it is not looked for by traditional medicine is that they really do not have a good way to treat it. They have not discovered any drugs to lower Lp(a). The only thing that appears to work is the specific type of pharmacological nutrient manipulation discussed by Pauling.