BIOTICS RESEARCH CORP. has presented us with the finest source of biologically available CALCIUM D-GLUCARATE on the market.
D-glucarate is a botanical extract found in grapefruit, apples, oranges, broccoli and brussels sprouts. Scientists are discovering that it appears to protect against cancer and other diseases via a different mechanism than antioxidants such as vitamin C, carotenoids, and folic acid. These vitamin antioxidants work by neutralizing toxic free radical damage in the body. There are however, other mechanisms by which the human body can detoxify itself. Glucuronidation is a detoxification process that occurs when toxins or carcinogens are combined with water-soluble substances, thus making them more easily removed from the body. D-glucarate has been shown to support this vital process by inhibiting an enzyme called beta-glucuronidase. When levels of this enzyme become elevated, it reverses the glucuronidation process and releases the toxins back into the bloodstream.
The results of various animal studies on D-glucarate indicate that this plant extract may be effective in enhancing overall immune function . The studies have demonstrated that D-glucarate suppressed beta-glucuronidase activity in the blood, liver, intestines, lungs, skin, and bladder. Calcium D Glucarate also ameliorates serum female hormone levels thus reducing the risk of female hormone related problems. CA D-GLUCARATE reduces a specific serum female hormone by inhibiting a bacterial enzyme in the gut which can cause the excess liver-excreted female hormone to be reabsorbed.
Human studies are just now beginning to determine if the results seen in animals will also be found in people. Since D-glucarate has no known side effects when ingested in moderate doses, and is a component of fruits and vegetables that have demonstrated powerful cancer preventative benefits, it would appear appropriate to add this plant constituent as part of an overall program designed to enhance our overall health.
Glucaric acid is a chemical made by the body and also consumed in foods. For dietary supplementation, it is combined with calcium to form calcium d-glucarate.
Because it is thought to hasten the elimination of potentially harmful substances from the body, glucaric acid has been promoted for enhancing our overall health. Calcium d-glucarate is known to decrease the amounts of an enzyme that is believed to be associated with certain immune problems – Additionally, glucaric acid interferes with the reabsorption of a specific female hormone from the gastrointestinal tract. As a result, more of this hormone is eliminated and less stays in the blood. While studies conducted in laboratory animals seem to confirm these theories, few studies have been conducted in humans. Furthermore, the doses of glucaric acid given to laboratory animals were quite large; equivalent human doses may be impractical. More research is needed before glucaric acid can be recommended for the prevention or treatment of of any disease condition.
Not enough is known about how glucaric acid or calcium d-glucarate might affect a developing baby or an infant, so it’s use is not recommended while pregnant or breast-feeding.
What side effects should I watch for?
No side effects have been associated with using glucaric acid. Since few reliable studies of its use have been conducted in humans, however, it may have side effects that are not yet known. If you experience unexplained side effects while taking glucaric acid, you should stop taking it and tell your doctor or pharmacist about the side effects.
What interactions should I watch for?
Because it is broken down by certain enzymes in the liver, glucaric acid may possibly interfere with the use of prescription drugs that are processed by the same enzymes. Some of these drugs are:
* diflunisal (Cataflam, Voltaren)
* ketoprofen (Orudis, Oruvail)
* lorazepam (Ativan)
In a research study, drinking alcohol seemed to increase the elimination of CALCIUM F-GLUCARATE from the body. Therefore, the effects of supplemental glucaric acid may be decreased or erased if alcohol is used at the same time.
Some interactions between herbal products and medications can be more severe than others. The best way for you to avoid harmful interactions is to tell your doctor and/or pharmacist what medications you are currently taking, including any over-the-counter products, vitamins, and herbals.
Glucaric acid and its salt, calcium d-glucarate may have some ability to protect against certain health problems by promoting the elimination of some toxic substances and potentially other harmful substances produced in the body. It may also have some effectiveness in lowering cholesterol and reducing kidney damage caused by some antibiotic drugs.
Although no apparent risks are associated with taking glucaric acid, pregnant and breast-feeding women are advised to avoid it because so little is known about its possible effects.
CA D-GLUCARATE (Calcium D-Glucarate)
Each capsule supplies:
Calcium (as Calcium D-Glucarate) 61 mg
Calcium D-Glucarate 500 mg
RECOMMENDATION One (1) capsule two (2) times each day as a dietary supplement or as otherwise directed by a health care professional.
Contains: 120 Capsules
Product #: 1740