Vitamin B12, an essential vitamin, is an indispensable coenzyme for two very important enzymes having key roles in internal metabolism. Methylmalonyl-CoA mutase is involved in fatty acid metabolism, and methionine synthase is involved in nucleic acid synthesis and methylation reactions.
Folic acid, like B12, is required for DNA synthesis. Folate is involved in protein synthesis and lipid metabolism.
Vitamin B6 is vital to numerous functions. They include immune function, glucoeogenesis, red cell metabolsim, lipid and neurotransmitter synthesis affecting the nervous system, and hormone function.
Oral Contraceptive-Drug/Nutrient Interactions
The use of oral contraceptives is associated with decreased folic acid, vitamin B12 and vitamin B6 levels. Among the areas of concern are the increased homocysteine plasma concentration (which impacts cardiac health), and in the case of pregnancy after cessation of oral contraceptive use, the increased risk of neural tube defects resulting from Folate depletion.
Nutritional Status and Age-related Hearing Loss in Elderly Women
Concern over B12 Folate status is not limited to women of childbearing age. Poor vitamin B12 and Folate status may be associated with age-related auditory function. Two of the most common vitamin inadequacies in the elderly are vitamin B12 and Folate.
B12 2000 Lozenges contain 2000 micrograms of vitamin B12 as Hydroxocobalamin and 800 micrograms of Folic Acid per lozenge. Use it with anemia, chronic fatigue, homocystinuria, digestive inflammation, low serum uric acid, elevated MCV or MCH, chronic debilitating problems, diabetes and neuromuscular disorders. To correctly identify a need for vitamin B12, a urinary or serum methylmalonic acid is performed. However, this is a pattern that will be accurate most of the time: If the MCV is above 89.9 in conjunction with an MCH above 31.9 (they have to be increased together), the probability of need for vitamin B12 is extremely high. Decreased uric acid (below 3.0) can also indicate a vitamin B12 need.
There is a doctor at Columbia University (considered to be one of the experts on vitamin B12 therapy), who has indicated that the oral forms of vitamin B12, if allowed to dissolve in the mouth, are extremely effective. By completing before and after tests using methylmalonic acid he was able to show a drop in methylmalonic acid when the patients let it dissolve in their mouth. If you are using the B12 2000 Lozenge, you may not want to chew it up and swallow it, but you might want to try and let it dissolve in the mouth. The suggested dose is normally one to three lozenges per day.
There is some evidence that a part of the uric acid we produce comes from the gut flora. This may be one of the reasons we see a decreased serum uric acid with some cases of vitamin B12 need. Furthermore, vitamin B12 is transported on a protein carrier; insufficient HCL levels in the stomach may also result in an increased need for vitamin B12 due to an inadequate protein carrier. In any case, when a vitamin B12 need is present, abnormal digestive function should be investigated, most especially a need for HCL.
Vitamin B12 need is common in vegetarians. If the vegetarian is not supplementing their diet with vitamin B12, the need is beyond common; it is almost certain. Therefore, if your patient is a vegetarian and not supplementing with vitamin B12, you can expect to find a deficiency of vitamin B12. Patients with hypochlorhydria and vegetarians are the two places we most often see a need for vitamin B12.
Along with Vitamin B6, B12 2000 Lozenges with Folic Acid is an excellent "two in one" product to keep Homocysteine levels normal.
B12 2000 LOZENGES
**Each lozenge supplies:
Vitamin B12 (as Hydroxcobalamin) 2000 mcg
Folic Acid 800 mcg
B12 2000 Lozenges also contain mannitol, sorbitol and natural lemon flavor.
SUGGESTED USE: One (1) lozenge each day as a dietary supplement or as otherwise directed by a health care professional.
Contains: 60 Lozenges
Product #: 1130