Cs – Cesium is found in igneous rocks at 1 ppm; shales at 5 ppm; sandstones and limestones at 0.5 ppm; fresh water at 0.0002 ppm; sea water at 0.00005 ppm; soils at 0.3 to 25 ppm; marine plants at 0.07 ppm; land plants at 0.2 ppm; and land animals at 0.064 ppm (highest concentrations in the muscle).
As an alkaline mineral, cesium behaves similarly to sodium, potassium and rubidium chemically. Cesium and potassium enter into a solute complex, which participates in ion antagonism, osmosis, permeability regulation and maintenance of the colloidal state in the living cell. The increase in supplemental potassium increases the rate of excretion or loss of cesium.
Cesium chloride is used as part of alternative cancer therapy. Cesium provides high pH therapy for cancer “by entering the cancer cell and producing an alkaline environment. It has been recommended for all types of cancers including sarcomas, bronchiogenic carcinoma and colon cancer.
Biological interest in rubidium and cesium has been stimulated by their close physicochemical relationship to potassium and their presence in living tissues in higher concentrations, relative to those of potassium, than in the terrestrial environment. Over a century ago Ringer observed that rubidium was similar to potassium in its effect on the contractions of isolated frog heart. Relationships between potassium and rubidium, and between cesium and potassium, have been found in a variety of physiological processes. These relationships exist in such diverse actions as their ability to neutralize the toxic action of lithium on fish larvae, or to affect the motility of spermatozoa, the fermentative capacity of yeast, and the utilization of Krebs cycle intermediates by isolated mitochondria. Their extracellular ionic concentrations also influence the resting potential in nerve and muscle preparations and the configuration of electrocardiograms.
The described metabolic interchangeability suggests that rubidium or cesium might have the ability to act as a nutritional substitute for potassium. Rubidium, and to a lesser extent cesium, can replace potassium as a nutrient for the growth of yeast and of sea urchin eggs. This nutritional replaceability can be extended to bacteria, but higher animals are more discriminating. Additions of rubidium or cesium to potassium-deficient diets prevent the occurrence of characteristic lesions in the kidneys and muscles in rats and, for a short period, permit almost normal growth until death inevitably supervenes.
The occurrence of cesium in biological samples has not been extensively studied. However, it has been found that, like rubidium, the cesium content is much higher in erythrocytes than plasma. Cornelis et al found a mean cesium concentration in serum of 0.74 ng/ml, and in red blood cells of 4.82 ng/g. Several other reports have also indicated that the cesium level in serum or plasma is in the range of 0.74 to 1.33 ng/ml. Both Clemente et al. and Hamilton et al. reported that whole blood contains ~5 ng/ml cesium. Like blood, other tissues contain cesium at a level of about one order of magnitude less than rubidium. Vanoeteren et al. found 9.1 ng cesium per gram of homogenized human lung. Wester found a median of 11.4 ng/g in human heart, and the cesium content was reduced in injured tissue of myocardial infarcted heart.
The cesium content of foodstuffs and feeds has not been examined extensively. Some isolated values have appeared, including 0.1-0.3 mcg/g dry fruit kernels, 0.06-0.07 mcg/g dry maple syrup, 0.1-0.3 mcg/g dry nuts except Brazil nuts, which contained 1.3 mcg/g, 9 ng/g fresh orange juice, and 12.1 ng/g fresh banana pulp. Most fruits and vegetables apparently are quite low in cesium. Duke found 3-11 ng cesium per gram dry weight, and Oakes et al. found Pharmacol Biochem Behav 1984; 21 Suppl 1:7-10
Nutrients and cancer: an introduction to cesium therapy.
A brief overview on the relevance in dietary factors in both development and prevention of cancer is presented. The pharmacologic properties of various food ingredients are discussed. Establishing of a special diet for the cancer patient is suggested. In addition, avoidance of certain foods is recommended to counteract mucus production of cancer cells. Evaluation of the nutrient content of certain diets in regions with low incidence of cancer has advanced the use of certain alkali metals, i.e., rubidium and cesium, as chemotherapeutic agents. The rationale for this approach termed the “high pH” therapy resides in changing the acidic pH range of the cancer cell by cesium towards weak alkalinity in which the survival of the cancer cell is endangered, and the formation of acidic and toxic materials, normally formed in cancer cells, is neutralized and eliminated.
Pharmacol Biochem Behav 1984; 21 Suppl 1:11-3
Cesium therapy in cancer patients.
The effect of cesium therapy on various cancers is reported. A total of 50 patients were treated over a 3 year period with CsCl. The majority of the patients have been unresponsive to previous maximal modalities of cancer treatment and were considered terminal cases. The Cs-treatment consisted of CsCl in addition to some vitamins, minerals, chelating agents and salts of selenium, potassium and magnesium. In addition, a special diet was also instituted. There was an impressive 50% recovery of various cancers, i.e., cancer of unknown primary, breast, colon, prostate, pancreas, lung, liver, lymphoma, Ewing sarcoma of the pelvis and adeno-cancer of the gallbladder, by the Cs-therapy employed. There was a 26% and 24% death within the initial 2 weeks and 12 months of treatment, respectively. A consistent finding in these patients was the disappearance of pain within the initial 3 days of Cs-treatment. The small number of autopsies made showed the absence of cancer cells in most cases and the clinical impression indicates a remarkably successful outcome of treatment.
The high pH therapy for cancer tests on mice and humans.
Mass spectrographic and isotope studies have shown that potassium, rubidium, and especially cesium are most efficiently taken up by cancer cells. This uptake was enhanced by Vitamins A and C as well as salts of zinc and selenium. The quantity of cesium taken up was sufficient to raise the cell to the 8 pH range. Where cell mitosis ceases and the life of the cell is short. Tests on mice fed cesium and rubidium showed marked shrinkage in the tumor masses within 2 weeks. In addition, the mice showed none of the side effects of cancer. Tests have been carried out on over 30 humans. In each case the tumor masses disappeared. Also all pains and effects associated with cancer disappeared within 12 to 36 hr; the more chemotherapy and morphine the patient had taken, the longer the withdrawal period. Studies of the food intake in areas where the incidences of cancer are very low showed that it met the requirements for the high pH therapy.
The response of colon carcinoma in mice to cesium, zinc and vitamin A.
Tufte MJ, Tufte FW, Brewer AK
Predetermined amounts of cesium chloride or carbonate, zinc gluconate and vitamin A were used together to alter growth of colon carcinoma (C38) implants in BDF1 mice. Data show that the use of these compounds in a treatment protocol is responsible for repression of tumor growth.
The effects of zinc gluconate, vitamin A and cesium salts on colon carcinoma in mice.
Tufte FW, Tufte MJ
Tests have been conducted using cesium salts, zinc gluconate and vitamin A on colon carcinoma (C38) implants in BDF1 mice. Preliminary work suggested a correlation between the repression of tumor growth and the use of these compounds. Present data show a high degree of tumor repression when selected amounts of these compounds are used together in a treatment protocol.
NOTE: Special thanks go to The Brewer Science Library (firstname.lastname@example.org) for their invaluable information. Also, thanks to Bio-Tech in Arkansas (800 345 1199) for providing us with Cesium tablets and capsules and to T-UP (410 850 5700) and Dr. Hoffman for his invaluable information on Cesium protocols.