The Importance of Phosphorylated (Activated) B Vitamins
Bio-3B-G® provides biochemically activate forms of the B vitamins, including riboflavin 5-phosphate and cocarboxylase, in lieu of riboflavin and thiamin, respectively. Consequently, fewer enzymatic steps are needed to achieve a fully functional coenzyme. As an example, the first step in the synthesis of NAD is the biochemical conversion of niacin to niacinamide, which then forms nicotinamide mononucleotide, an intermediate for NAD formation.
Riboflavin 5-phosphate is the redox co-enzyme FMN, converted in a single step by flavokinase to FAD, which is more frequently used than FMN. Flavokinase is regulated by thyroxin, and in adults hypothyroidism may be associated with riboflavin deficiency. In addition, Bio-3B-G® provides two complete coenzymes, pyridoxal 5-phosphate and thiamine pyrophosphate (also known as cocarboxylase).
Activation of vitamin B6 involves the phosphorylation of pyridoxine (vitamin B6) to pyridoxine phosphate and its subsequent oxidation to the coenzyme pyridoxal 5-phosphate, the activated form of vitamin B6. Bound to albumin in the blood, pyridoxal 5-phosphate characterizes a major storage site and transporter for vitamin B6. In the blood serum of healthy persons, pyridoxal 5-phosphate comprises from between 25% and 60% of the circulating vitamin B6. The liver is the primary site of pyridoxal 5-phosphate formation. Thus it is not surprising that up to 90% of people with liver disease, like cirrhosis, are deficient in vitamin B6.
Due to the fact that Bio-3B-G® supplies three times the amount of thiamine (B1) pyrophosphate and 100% RDA of the B vitamin group, including B2, B3, B6 and B12, it may be a beneficial adjunct in nutritionally supporting normal homeostatic mechanisms, particularly during stress and/or with elevated blood pressure.
**Three (3) tablets supply:
Thiamin (B1) (as cocarboxylase) 4.5 mg
Riboflavin (B2) (as riboflavin-5-phosphate) 1.7 mg
Niacin (as niacinamide 20 mg
Vitamin B6 (as pyridoxal-5-phosphate) 2 mg
Vitamin B12 (as methylcobalamin) 6 mcg
Biotin 300 mcg
Pantothenic Acid (B5) (as calcium pantothenate) 10 mg
Superoxide Dismutase (raw organic vegetable culture) 60 mcg
Catalase (raw organic vegetable culture) 60 mcg
RECOMMENDATION: One (1) to three (3) tablets three (3) times daily as a dietary supplement or as otherwise directed by a healthcare professional.
Contains: 180 Tablets
Product #: 1137