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KAPPAREST - NF-kappaB Inflammatory Blocker

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180 Capsules for : $47.90

NOTE: Biotics Research Corp. has analyzed dozens of Tumeric/Curcumin preparations in the market place. I was told by one of their biochemists that EVERY Curcumin product they tested with their Spectrograph equipment showed that all the Curcumin products had traces of solvents that were left over from the extracting process from Tumeric. So, I asked them about the Curcumin Biotics uses and he said " It is probably there, but our equipment could NOT detect any of the solvents."

This product provides broad antioxidant support and supplies a broad array of phytonutrient compounds that have been shown to suppress activation of NF-kappaB and AP-1 and the associated kinases. NF-kappaB is a molecule inside each cell that becomes activated to stimulate the production of inflammatory chemicals that promote pain, inflammation, and a variety of problems.

New research is showing that many disease conditions are associated with inappropriate activation of Nuclear Transcription factor kappaB (kappa-Beta), generally referred to as NF-kappaB. Inhibition of NF-kappaB is now a major therapeutic goal in the treatment and prevention of a wide range of illnesses, including cancer, arthritis (degenerative and rheumatoid), autoimmune diseases, and neurological illnesses such as Alzheimer's and Parkinson's disease.

What does KappArest do for the body?
The inflammatory cascade initiated by an enviromental trigger can lead to the activation of NF-kappaB (nuclear factor kappa-light-chain-enhancer of activated B cells). NF-kappaB is a protein complex that acts as an intracellular ‘amplifier’ that promotes the production of the direct mediators of inflammation such as cytokines, prostaglandins, leukotrienes, nitric oxide, and free radicals. If NF-kappaB is not inhibited, it becomes free to enter the nucleus of cells and bind with the DNA, subsequently activating genes which encode for the increased production of further inflammatory mediators. When left unchecked, this can lead to the development of health issues such as pain, inflammation, cardiovascular degeneration, insulin resistance, autoimmune disorders, free radical pathology, and neurodegeneration.

Unfortunately, inflammation has become overwhelmingly prevalent, largely in part to the pro-inflammatory nature of the Standard American Diet (SAD) and the nutritional deficiencies resulting from it, stress-laden lifestyles, and other constant environmental insults.

Formulated in conjunction with Alex Vasquez, D.C., D.O., KappArest™ contains a proprietary blend of curcuminoids (turmeric extract), Boswellia serrata extract, propolis, green tea extract, ginger extract, rosemary extract, celery seed extract, resveratrol, alpha-lipoic acid, Phytolens, and Piper nigrum.

KappArest™ was designed to supply targeted nutrition in order to inhibit the production of NF-kappaB.


Three (3) capsules supply:
Proprietary Blend: 1,150mg
- Curcumonoids (turmeric extract)(rhizome)
- Boswellia serruta extract (gum)
- Propolis
- Green tea extract (camellia sinensis)(leaves)
- Ginger extract (rhizome)
- Rosemary extract (leaves)
- Celery seed extract
- Resveratrol (polygonium cuspidatum extract)(root)
- Alpha Lipoic Acid
- Saccharium officinarium extract (shoots)
- Phytolens™ (lens esculenta extract)(husks)
- BioPerine® (from piper nigrum)
(BioPerine® is a registered trademark of Sabinsa Corp.)
- Other ingredients: Cellulose, gelatin, water and glycerin

RECOMMENDATION: Three (3) capsules two (2) times daily as a supplement or as otherwise directed by a healthcare professional.

CAUTION: Not recommended for pregnant or lactating women.

Product #: 7855
Contains: 180 Capsules
NDC: 55146-07855

CURCUMIN, additional information.

Curcumin (Diferuloylmethane) is a compound found in the Indian curry spice, tumeric.

It has been discovered that people in India have a very low incidence of neurological diseases and researchers have attempted to find out why this is. They have looked at the spice, tumeric, which was known from traditional Indian medicine as an anti-inflammatory agent effective in wound healing. Research using curcumin, the active ingredient of tumeric, in EAE, a mouse model of multiple sclerosis, has shown that it may be of benefit to people with MS.

Curcumin is not to be confused with cumin which is a completely different spice with a similar name.

There are a number of scientific papers which have looked at how curcumin might help with neurodegenerative diseases. Among the beneficial effects that curcumin may have are:

* Inhibiting the passage of a type of white blood cell called a macrophage into the brain from the blood. This normally happens by the macrophage sticking to the "endothelial cells" on the inside of the blood vessels.
* Blocking a body tissue reshaping protein called MMP-9 which is known to be involved in process of myelin destruction done in MS.
* Inhibiting the release of a signalling molecule called TNF- which is also involved in the damage caused by MS.
* Reducing oxidative activity in glial cells.

More work has shown that piperine, the spice in black pepper, increases the bio-availability of curcumin by 2,000%.

It is unclear how much curcumin/tumeric one should eat to get the maximum benefit. This is early days but some people are using 1.5 grams (about a teaspoon) of tumeric per day. You can buy curcumin/tumeric in capsule form although I am unsure whether anyone makes curcumin capsules with piperine in them.

180 Capsules for : $47.90

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