M C S, “Metabolic Clearing Support,” is a unique dietary supplement designed to balance Phase I and Phase II pathways in the liver. This supplement combines nutritional support of vitamins, sulfur bearing amino acids, parotid glandular and herbal adaptogens.
M C S
**Each capsule supplies:
Vitamin A (as natural m xed carotenoids] 1,000 IU
Vitamin C (ascorbic acid) 30 mg
Vitamin E (as d-alpha tocopheryl acetate) 30 IU
Vitamin B1 (as thiamin mononitrate) 1 mg
Vitamin B2 (as riboflavin) 2 mg
Niacin (as niacinamide and niacin) 3 mg
Vitamin B6 (as pyridoxine HCI) 2 mg
Folic Acid 400 mcg
Pantothenic Acid (as calcium pantothenate) 10 mg
Magnesium (as magnesium aspartate) 25 mg
Zinc (as zinc gluconate) 2 mg
Selenium (from vegetable culture) 20 mcg
Copper (as copper gluconate) 0.2 mg
Molybdenum (from vegetable culture) 30 mcg
Choline (as choline bitartrate) 20 mg
Parotid Tissue (bovine] 20 mg
L-Methionine 100 mg
N-Acetyl -L-Cysteine 50 mg
Taurine 50 mg
Glutathione (Reduced) 30 mg
Quercetin 20 mg
Proprietary blend 90 mg of Red Clover (flower), Boldo (leaf), Burdock (root), Culvers-root, Joe-Pye.
WARNING: Not recommended for pregnant or lactating women,
RECOMMENDATIONS: One (1) capsule twice each day as a dietary supplement or as otherwise directed by a health care professional.
Contains: 90 Capsules
Product #: 6320
The body is constantly exposed to a wide variety of potentially damaging substances. Many are products of metabolism or naturally occurring toxins in food or synthetic chemicals. Endogenously produced toxic agents, endotoxins, include products of microbial metabolism as well as lipopolysaccharides. Xenobiotics include plasticizers, organic solvents, pesticides and industrial wastes that can contaminate water, food and air, as well as same medications.
To meet the challenge of toxins, the body employs an array detoxication systems. Detoxication is primarily the responsibility of the liver. Water-soluble compounds are generally cleared from the bloodstream by the kidney; some of the modified toxins are released in the bile. Fat-soluble xenobiotics accumulate in fatty deposits. To dispose of these materials, phase I adds or unmasks functional groups. The resulting products are either modified by phase II, or they may be excreted directly. Phase II generally adds highly polar compounds to make the toxin more water-soluble and thus, more readily eliminated (biotransformation).
The levels of phase I and phase II enzymes reflect genetic polymorphism, as well as the degree of induction or repression. Excess sugar and sodium may depress detoxication and reduce liver function. Many nutrient deficiencies also impair liver function, including glutathione, magnesium, calcium, copper, zinc, niacin, riboflavin and vitamin B6, as well as vitamin C and vitamin E.
In terms of oxidation, the cytochrome 450 monooxygenases predominate. In humans, most of the work is performed by only six major types. Cytochrome P450s require a flavoprotein, cytochrome 450 reductase, which requires NADPH as a reducing agent. Besides cytochrome P450s, flavin-containing monooxygenases (FMOs) perform other important oxidations. FMOs require FAD and NADPH. Therefore, both riboflavin and niacin directly support Phase I. NADPH is derived primarily from carbohydrate metabolism (the pentose phosphate pathway) which relies on thiamin. Magnesium is required for most reactions involving ATP and this mineral supports detoxication via glucose metabolism.
Cytochrome P450s are membrane-bound enzymes; therefore, perturbations of membranes, such as the peroxidation of polyunsaturated fatty acids in membrane lipids, can alter P450 activity. Reactive oxygen species are likely products of Cytochrome P450 (4). This “leakage” contributes to oxidative stress associated with detoxication. In addition, certain P450 isozymes yield epoxides of polycyclic aromatic compounds, the same kinds as found in cigarette smoke, which are potentially cytotoxic and mutagenic.
Activation of the P450 pathway can deplete antioxidant defenses, therefore supplemental antioxidants may be beneficial.
Glutathione – quenches free radicals, reactive oxygen species directly, and it reduces cytoplasmic and peroxides via glutathione peroxidases. It occurs in the cytoplasm in very high concentrations to maintain the internal redox environment. By keeping proteins reduced, glutathione promotes cellular maintenance and repair. Lowered glutathione is linked to aging and to increased susceptibility to oxidative stress. Oral glutathione can increase plasma glutathione levels.
N-Acetylcysteine – is an easily absorbed precursor of cysteine, which is used to form glutathione. N-Acetylcysteine helps restore depleted glutathione.
Vitamin C – is an excellent free radical quencher. It can prevent the formation of nitosoamines, which can be powerful mutagens. Vitamin C is required for optimal production of cytochrome P450 and FMOs.
Vitamin E – is the premier lipid antioxidant. It is localized in membranes where it reduces alkoxyl and peroxyl radicals. The tocopheryl radical can be reduced back to vitamin E by vitamin C, reduced coenzyme Q10 and reduced glutathione.
Carotenoids – include carotenes, such as alpha carotene and beta carotene, as well as xanthophylls including zeaxanthin and lutein. Carotenoids quench singlet oxygen and free radicals at low oxygen tension and they support the immune system. Mixed natural carotenoids may be more readily absorbed and more effective antioxidants in vivo than pure, synthetic beta carotene.
Quercetin– is a flavonol, prevalent in fruits and vegetables. Quercetin protects against lipid peroxidation. Recent studies suggest that appreciable dietary quercetin is absorbed. It inhibits the activation of aflatoxin B, and the hydroxylation of benzo(a) pyrene. Quercetin has other physiological actions, including the inhibition of the arachidonic acid cascade enzymes.
Copper – is a cofactor required by superoxide dismutase (SOD). This enzyme “dismutes” superoxide to 02 and hydrogen peroxide. Zinc, too, is a cofactor for SOD. In addition, zinc protects plasma membranes from oxidation, independently of its participation in the disposal of superoxide. As a cofactor for alcohol dehydrogenase, zinc plays a key role in detoxifying ethanol. Selenium as selenocysteine is required by glutathione peroxidases, a family of enzymes that degrade hydrogen peroxide as well as peroxides of polyunsaturated fatty acids, to protect membrane lipids. Molybdenum is a cofactor for aldehyde oxidase as well as sulfite oxidase.
Phase II detoxication enzymes add highly polar compounds to chemically modified toxins or waste products. Taurine, glutathione, glycine, glutamine, glucuronic acid and sulfate are common examples.
Glutathionetransferases couple glutathione to a wide array of Phase I products. Orally administered glutathione increases plasma levels of glutathione and protects sperm for example.
Conjugation with amino acids requires pantothenic acid, the vitamin precursor of coenzyme A. Pantothenic acid may stimulate the production of reduced glutathione.Taurine confers water solubility to compounds such as bile salts and steroid hormone metabolites.
Methionine plays a central role to detoxication: It forms cysteine – used for glutathione and coenzyme A synthesis and for the formation of taurine, and is the ultimate source of sulfate used in conjugation. Furthermore, methionine forms the methyl donor for the synthesis of phospholipids and membranes such as the endoplasmic reticulum where many of the detoxication systems are localized.
Choline, too, is a precursor of phospholipids. Reconstituted cytochrome P450 and NADPHcytochrome P450 reductase require phosphatidy1choline. Vitamin B6 supports both phospholipid synthesis and the formation of cysteine from methionine.
MCS supplies a unique blend of herbs to support detoxication:
Arctium lappa (Burdock root) – The dried root contains inulin and mucilage that are fructosebased polysaccharides. A complex essential oil contains methoxypyrazines, polyacetylenes, sulfur-containing acetylene derivatives such as aretic acid, arctitonone, and arctinol, and costus acids and lactones. Burdock root has a tradition of supporting liver functions and bile production.
Eupatorium purpureum (queen of meadow root) – Has traditionally been used to support the liver and its cleansing functions.
Leptandra virginica (Culver’s root) – Traditionally this herb has been used to support normal liver function and bile production, and more generally to support digestion and absorption.
Peumus boldus (boldo leaf) – This plant is a native of Chile. It contains boldine, together with ascaridole, P-cymol, cineole and other monoterpenes. In folk traditions boldo has been used to support normal function of the gastrointestinal tract, including bile production and is noted for its soothing actions. Boldo possesses antioxidant activity and it has been shown to normalize immune reactions. Extracts reduce lipid peroxidation in hepatocytes exposed to peroxides. Contraindications: Boldo is contraindicated when there is obstruction of the bile duct or serious liver conditions.
Trifolium pratense (red clover) – In addition to tannins, red clover contains isoflavones, including biochanin A and coumesterol. The effects of these substances on xenobiotic processing by mammalian cell cultures have been noted. Daidzen and genistein are also important ingredients of red clover. These isoflavones are the focus of current research. In addition, coumarins help balance immune functions in the liver and spleen.
Parotid Tissue (bovine) – Salivary glands are integrated into the neuroimmunoregulatory network. For example, factors extracted from the submandibular gland of lab animals stimulate lymphocyte proliferation. Salivary factors have been proposed to support the mucosal responses in the gastrointestinal tract and maintenance and regeneration, in addition to the well-established roles of secretory IgA, essential for host defense.